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KMID : 1123920070210061569
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Korean Journal of Oriental Physiology and Pathology
2007 Volume.21 No. 6 p.1569 ~ p.1575
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Improved Regenerative Responses of Injured Spinal Cord Nerve Fibers by the Treatment of Sukjihwang(Rehmanniae radix preparat)
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Han Gyu-Seol
Seol In-Chan
Yoo Ho-Rhyong
Cho Hyun-Kyoung
An Joung-Jo
Namgoong Uk
Kim Yoon-Sik
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Abstract
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In oriental medicine, Sukjihwang (SJH, Rehmanniae radix preparat) has been used as one of the key ingredients for the prescription of several herbal decoctions and applied clinically for the treatment of several diseases including nervous system and cardiovascular disease. Here, possible growth-promoting effects of SJH on injured spinal cord axons were investigated in the rats. SJH administration increased levels of active form of ERK1/2 protein and Cdc2 proteins in the injured spinal cord tissue. Anterograde DiI-tracing of corticospinal tract axons showed that SJH-treatment enhanced axonal arborization in the injury area and extensive axonal extension into the caudal area. In SJH-treated group, glial scar formed after spinal cord injury was confined in a smaller area compared to the control group, and the trabecula structure was well observed within the injury cavity. Furthermore, increased proliferation and migration of astrocytes in the injury cavity were observed by SJH treatment. Thus, these present data provide a biological evidence on potential importance of SJH therapy for the treatment of injured spinal cord.
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KEYWORD
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Sukjihwang (SJH, Rehmanniae radix preparat), injured spinal cord, ERK1/2 protein
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